The endocannabinoid system (ECS) has been around since the beginning of vertebrate species, but why did we never learn about it in vet or tech school? With numerous pharmaceuticals and plant-based options targeting the ECS receptors we will delve into what the ECS really is and does in the mammalian body in regard to pain management. We will also discuss the endocannabinoidome, which is a more recent expansion of the ECS. Attendees will learn in brief the system of receptors cannabinoids works on. They will be introduced to the current literature in small animals in relation to cannabinoids as well as have a practical understanding of using cannabinoid in practice.